| Characteristic | Description |
|---|---|
| Name | Sildigra |
| Active Ingredient | Sildenafil Citrate |
| Common Dosages | 100 mg |
| Form | Tablets |
| Use | Erectile Dysfunction |
| Link | Learn More about Sildigra |
Pharmacokinetics
Sildigra 100 mg showcases remarkable pharmacokinetic properties. Upon oral administration, sildenafil citrate is rapidly absorbed. Peak plasma concentrations occur within 30 to 120 minutes. The drug exhibits a half-life of approximately 3 to 5 hours. Metabolism occurs primarily via hepatic pathways. Cytochrome P450 enzymes, notably CYP3A4, play a significant role. Approximately 80% of the administered dose is excreted in feces and 13% in urine. Bioavailability of the oral dose is about 41%. High-fat meals can delay absorption, impacting peak concentration.
The binding affinity to plasma proteins is around 96%. This high binding capacity means only a small fraction circulates freely in the bloodstream. Factors such as age, renal, and hepatic impairment can influence the pharmacokinetics. Individuals with compromised liver function may exhibit increased plasma concentrations. Dose adjustments could be necessary in such populations. Monitoring plasma levels may provide additional insight.
Mechanism of Action
The mechanism of action of Sildigra is rooted in the modulation of cyclic GMP. Sildenafil, its active component, acts as a potent phosphodiesterase type 5 (PDE5) inhibitor. This enzyme is responsible for the degradation of cyclic GMP in the corpus cavernosum. By inhibiting PDE5, sildenafil enhances the effect of nitric oxide, a natural mediator. This leads to increased levels of cyclic GMP, resulting in smooth muscle relaxation. As a result, blood flow to the penis is enhanced, facilitating an erection.
It’s crucial to note that sildenafil does not induce erections without sexual stimulation. The drug only potentiates the physiological erectile response. Its efficacy has been established in various populations, including those with diabetes and spinal cord injuries. However, the impact on libido is minimal, as it predominantly addresses vascular mechanisms.
Sildigra Contraindications
Sildigra 100 mg is not suitable for everyone. Contraindications include known hypersensitivity to sildenafil or any tablet components. Concurrent use with nitrates or nitric oxide donors is prohibited. This combination may result in severe hypotension. Patients with severe cardiovascular disorders should refrain from using Sildigra. These include unstable angina, severe cardiac failure, and recent history of myocardial infarction.
Individuals with significant hepatic impairment or hypotension should avoid Sildigra. Caution is advised for those with retinitis pigmentosa, as PDE5 inhibitors may affect vision. Concurrent use with other PDE5 inhibitors or treatments for erectile dysfunction is not recommended. This could increase the risk of adverse effects without improving therapeutic outcomes.
Cautions with Other Medicines
Sildigra 100 mg can interact with several medications. Potent CYP3A4 inhibitors like ketoconazole and erythromycin can increase sildenafil levels. Patients using such agents may require dose adjustments. Alpha-blockers, used for hypertension or prostate issues, pose another concern. Combining these with Sildigra may lead to symptomatic hypotension. It’s crucial to maintain stability before introducing sildenafil.
Nitrates, often prescribed for angina, should never be used with Sildigra. This could cause severe blood pressure drops. Herbal supplements, such as St. John’s Wort, can also alter the drug’s metabolism. It’s essential to inform healthcare providers about all concurrent medications. Adjustments or monitoring might be necessary to ensure safe use.
Sildigra Side Effects
Sildigra, like many pharmaceuticals, can cause side effects. Common ones include headache, flushing, and nasal congestion. Gastrointestinal disturbances like dyspepsia may occur. Some users report dizziness and visual changes. These often involve a bluish tinge to vision or light sensitivity. Such symptoms usually resolve after discontinuation.
Serious adverse effects, though rare, require immediate medical attention. These include sudden hearing loss, chest pain, or priapism. The latter is a prolonged erection lasting more than four hours. This condition demands prompt intervention to prevent tissue damage. Monitoring and dosage adjustments can minimize risks.
Sildigra Over The Counter
Sildigra 100 mg remains a prescription medication. It’s vital to consult a healthcare professional before use. They can assess the appropriateness based on individual health status. Self-medicating poses significant risks, especially with underlying health conditions.
Some may seek over-the-counter options. However, such alternatives might lack the efficacy and safety profile of Sildigra. Authenticity and quality assurance remain concerns with non-prescription variants. To achieve the desired therapeutic outcome, adherence to prescribed guidance is paramount.
While lifestyle adjustments and psychological support can complement treatment, they cannot replace pharmacological interventions. Ensuring a comprehensive approach maximizes benefits and minimizes potential hazards.
- Peak absorption within 30 to 120 minutes
- Metabolized by CYP3A4 enzymes
- High protein binding (96%)